Coat shallow 12 x 7-inch baking dish with nonstick cooking spray.
Toss together bread, spinach, pepperoni, tomato, cheese and Italian seasoning in large bowl. Spread evenly in prepared dish.
Whisk together eggs, half-and-half, salt and pepper in a bowl. Pour evenly over bread mixture. Cover with plastic wrap. Refrigerate at least 2 hours or overnight.
Heat oven to 425 degrees F. Remove dish from fridge; let stand 5 minutes. Remove plastic wrap; cover with foil.
Bake in 425 degree F oven for 15 minutes. Uncover; bake 15 minutes. Let cool slightly and serve. Makes 6 servings.