Spray a large nonstick skillet with canola oil; set aside.
Lay 6 slices of bread on your work surface. Keeping edges free of food, place a generous teaspoon of cream cheese, a generous teaspoon of fruit spread, and 4 or 5 strawberry slices on each piece. Top with remaining bread.
In a medium mixing bowl, combine eggs, milk, and vanilla. Dip sandwiches in the egg mixture, being careful not to let strawberries fall out. Press edges together to seal.
Heat skillet to medium. Cook each French toast sandwich 2 or 3 minutes or until the first side is golden brown. Use a spatula to turn sandwich over, and cook until second side is golden brown. Sprinkle with powdered sugar. Serve immediately with maple syrup, if desired.