Pregnancy My Pregnant Body Can I take Tylenol PM when I'm pregnant? By Parents Editors Published on July 2, 2015 Share Tweet Pin Email Q: Is it okay to take Tylenol PM every night of my pregnancy for the whole nine months? A: Tylenol PM is simply a combination of Tylenol and Benadryl. Although both of these medications are considered safe during pregnancy, long-term Benadryl use is not recommended as you can build up a tolerance to the medication, and there are reports of depression, brain and/or stomach damage, and other problems such as withdrawal seizures. Answered by Dr. Marra Francis Was this page helpful? Thanks for your feedback! Tell us why! Other Submit