The research, which comes out of Warwick Medical School and University Hospitals Coventry and Warwickshire NHS Trust and was published in the Journal of the Federation of American Societies for Experimental Biology, shows the way in which those genes turn off for a period of time to allow an embryo to implant in the uterus, a key piece of the timing puzzle for conception.
Looking at endometrial cells from the linings of both healthy women as well as those who had experienced miscarriage multiple times, the researchers found that women who experienced those losses might be less capable of regulating the clock genes in their uterine lining.
The study also offers insights about how fertility may be affected in women with atypical work hours—like night shifts.
Most importantly, of course, the researchers hope that identifying this cause of multiple miscarriages might be able to help more people conceive—huge news for anxious couples who are TTC. And it could have significant implications related to IVF, if doctors were able to use knowledge about bio-rhythms to have more success with implanting embryos.
Professor Siobhan Quenby, a consultant obstetrician at Warwick Medical School and UHCW NHS Trust said in a statement, "We hope that [the study] will increase worldwide knowledge about possible reasons for infertility and recurrent miscarriages, so that we are able to help families achieve their dream of having children."
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