This discovery as to what causes women to suffer recurrent miscarriage may lead to treatment options.

By Meagan Morris

Experiencing one miscarriage is devastating enough, but for some women it happens again and again. Medical experts haven't been able to make a connection as to why some women experience multiple miscarriages, but researchers from the University of Warwick think they have the answer.

Professor Jan Brosens and his team discovered that a lack of stem cells in the womb lining is likely responsible for miscarriages in "thousands" of women.

"We have discovered that the lining of the womb in the recurrent miscarriage patients we studied is already defective before pregnancy," the professor of obstetrics and gynecology wrote in the study, published in the journal Stem Cells in 2016.

Why stem cells matter in pregnancy

For the study, Brosens and his team studied tissue samples from the womb linings donated by 183 women being treated at the Implantation Research Clinic, University Hospitals Coventry and Warwickshire NHS Trust. They found that an "epigenetic signature" common with stem cells was missing from the tissues of women who have suffered more than one miscarriage.

Their findings are notable because although miscarriage is relatively common—between 15 and 25 percent of pregnancies end this way—only one in 100 women trying to conceive suffer three or more consecutive pregnancy losses.

The team also found that a lack of stem cells increases the aging rate of cells in the womb. The uterus relies on stem cells to regenerate after menstruation, pregnancy and miscarriage; the lack of those cells—and the aging process—creates an inflammatory response that affects the ability for a fetus to grow to full term.

"After an embryo has implanted, the lining of the uterus develops into a specialized structure called the decidua, and this process can be replicated when cells from the uterus are cultured in the lab," wrote Brosens. "Cultured cells from women who had had three or more consecutive miscarriages showed that aging cells in the lining of the womb don't have the ability to prepare adequately for pregnancy."

In other words, the body can't fully renew itself to make a welcoming environment for a baby.

Hope for hopeful mothers

While this research paints a bleak picture, there is hope. The team believes that this discovery will lead to treatments that will stimulate the function of stem cells in women without them—and they're already working on new interventions.

"Our focus will be two-fold," said Siobhan Quenby, study co-author and University of Warwick Professor of Obstetrics. First, they'll work to improve how at-risk women are screened through new endometrial tests.

"Second, there are a number of drugs and other interventions, such as endometrial 'scratch', a procedure used to help embryos implant more successfully, that have the potential to increase the stem cell populations in the womb lining."

Added Brosens: "I can envisage that we will be able to correct these defects before the patient tries to achieve another pregnancy. In fact, this may be the only way to really prevent miscarriages in these cases."


Comments (1)

December 15, 2018
Hello! Hello!! Hello!!! Viewers Great opportunity is out now……Do anyone still doubt natural herbs? We all know that herpes is one of the most common sexually transmitted diseases, prompting many to wonder how to get rid of herpes naturally. Unfortunately, they did not find a definite solution to herpes but today i have bring you the great opportunity we all have been waiting for because I’ve seen the great importance of natural herbs and the wonderful work they have done in people’s lives. I wonder why people still spend their money on surgery, injections and drugs each time they are sick or diagnose. Natural herbs can cure all kinds of illness including herpes, diabetics, asthma, HIV, hepatitis, etc. I’ve seen it with my own eyes. I was cured of Herpes and my aunt and her husband were cured of HIV by Dr. Oduku who uses natural herbs to cure different kind of illness. Even Dr. Oduku have prove to the whole world that natural herbs can cure all diseases and it cured countless of people using natural herbs. I know is hard to believe but am a living testimony. There is no harm in trying herbs.You can reach Dr Oduku through his email at or God bless you!!