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The vaccine against pertussis, which is commonly known as whooping cough, has been perplexing researchers who are observing that it's less effective than anticipated at halting the spread of the disease.  2012 was the worst whooping cough outbreak in 50 years, and the continued presence of the disease is troubling, especially as many families choose not to have their children vaccinated--or to get Tdap booster shots themselves.

Image: Child coughing, via Shutterstock