Smoking During Pregnancy Raises Kids' Substance Abuse Risk

According to the Centers for Disease Control, 13% of women say they smoked during the last three months of their pregnancy, despite studies that have correlated lighting up with an increased risk of birth defects and heart trouble for their children. Now, a new study published in the journal JAMA Psychiatry adds to that list of risks, showing that exposure to smoke in utero may interfere with proper development of the baby's reward processing system in the brain.

Researchers from Technische Universität Dresden in Germany compared 177 teens between the ages 13 to 15 who had been exposed to cigarettes prenatally to 177 teens whose mothers did not smoke while expecting. To test how the teens reacted to being presented with a reward — which simulated the need to satisfy an addiction — the participants were placed in a functional MRI (fMRI) scan to record their brain activity while they performed specific computer-based tasks. The teens were asked to press a button indicating on which side of the screen a figure popped up, and they were told there would be a reward if they were able to press the correct button fast enough. The scientists also varied the time that the targets appeared on the screen in order to evaluate how quickly the teens processed the anticipated task. Based on previous work with animals that suggested that activity in a specific area of the brain, the ventral striatum, was depressed by nicotine, the researchers focused their attention on this region of the adolescents' brains.

Indeed, they saw less activity in this area of the brain among the teens whose were exposed to smoke in the womb compared to those who were not, which resulted in longer times to respond to the target. Similar inhibited responses may be behind some addictions, since muted activity of the brain chemicals that signal satisfaction may prompt people to continue to seek this "high" and become dependent on addictive substances or behaviors. "The weaker responsivity of the ventral striatum to regard anticipation in prenatally exposed adolescents may represent a risk factor for substance use and development of addiction later in life. This result highlights the need for education and preventive measures to reduce smoking during pregnancy," the study authors wrote.

Image: Pregnant woman smoking, via Shutterstock


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