Home Health Parents News Now Drug May Be Able to Correct Autistic Behaviors in Some Drug May Be Able to Correct Autistic Behaviors in Some By Holly Lebowitz Rossi April 12, 2012 Advertisement Save Pin FB More Tweet Email Send Text Message Print Drug May Be Able to Correct Autistic Behaviors in Some 29595 A study out Wednesday in the journal Neuron found that medication could correct the health and behavior problems of mice with a genetic condition known to lead to autism in people. The drug, which acts on the synapses, or gaps, between brain cells, reversed a vast range of symptoms often associated with autism -- including lack of sociability, physical awkwardness, and hyperactivity. Most surprising, the drug worked on adolescent mice, showing that these symptoms are reversible even after the critical period of early brain development. "I was thrilled," said Mark Bear, the MIT neuroscientist who led the research. Bear helped found a company, Seaside Therapeutics, which is currently studying a similar drug in people with Fragile X, a genetic condition that often leads to autism. The mice had the same genetic change as the people in the study. Roche and Novartis are also studying similar medications, with effectiveness trials due to be completed in about a year. "I can't tell you how exciting it is right now, and how anxiously I am awaiting the impact of these clinical trials," Bear said. "It seems that in Fragile X and maybe other causes of autism there is essentially a metabolic problem." The problem in Fragile X, Bear said, seems to be that there are too many proteins being produced in the junctures between brain cells. Flooded with proteins from one brain cell, the receptors at another don't know which protein to accept, and, essentially, a traffic jam results. Bear said he was amazed, several years ago, when he realized that a tie-up between brain cells could cause the full range of symptoms found in autism. "It truly is extraordinary that this receptor seems to give rise to so many aspects of the disease," he said. Image: Prescription pad, via Shutterstock. By Holly Lebowitz Rossi Save Pin FB More Tweet Email Send Text Message Print Comments Add a Comment Be the first to comment! No comments yet. Advertisement Close this dialog window Add a comment Drug May Be Able to Correct Autistic Behaviors in Some Add your comment... Cancel Submit Success! Thanks for adding your feedback.