Taking anti-inflammatory drugs like ibuprofen and naproxen in early pregnancy appears to more than double the risk of miscarriage, MSNBC.com reports.
In a new study, researchers combed through medical records of almost 50,000 pregnant women in Canada and found that women who took non-steroidal anti-inflammatory drugs (or NSAIDS) before twenty weeks "were 2.4 times as likely to have a miscarriage as those who did not. The rate of miscarriage in women who took NSAIDs was about 35 percent, compared with the normal rate of miscarriage, which is about 15 percent," MSNBC said. From that article:
"I would strongly suggest that women take no non-steroidal anti-inflammatory drugs during the first trimester," said study co-author Anick Berard, a professor of epidemiology at the University of Montreal and director of the research unit on medications and pregnancy at Centre Hospitalier Universitaire Ste. Justine. "If a woman is taking an NSAID for a chronic condition she really has to talk to her health care provider to see if it's feasible to stop at least during the first trimester."
But Dr. Hyagriv Simhan, associate professor and chief of the division of maternal-fetal medicine at the University of Pittsburgh Medical Center, warned against overreacting: "I wouldn't want this to be a reason for women who have taken a Motrin before they realized they were pregnant to freak out," he said.
Simhan also pointed out a limitation of the study, that some of the women may have taken NSAIDs to cope with cramping from a miscarriage already underway. But the researchers say it's unlikely that influenced their findings.
The study did not look at over-the-counter NSAIDs, since Canadians usually get these drugs by prescription. But the researchers warned that taking "any type or dosage" in pregnancy may be risky.
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