A: Trouble sleeping is normal is pregnancy. I tell my patients that they should avoid caffeine or drinking excessive fluid in the evening hours to try and prevent needing to use the restroom at night. Sleep aids are safe depending upon the type. Tylenol PM is simply acetaminophen mixed with benadryl and both drugs alone are considered safe in pregnancy so the combination is also assumed to be a safe sleep aid. Any other sleep aids that are prescription needs to be discussed with your OB.