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Cincinnati Children's Hospital Medical Center

Cincinnati Children's is one of Parents magazine's 10 best hospitals for 2013.

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-As a major Children's Research Center, we make changes happen every year, big changes. What you about to see is a brief look at what has happened this year at Cincinnati Children's. As impressive as these discoveries are, they are just part of a much more extensive and fruitful body of work. You can find detail summaries of all of our research on our website. I'm Arnie Strauss, director of the Cincinnati Children's Research Foundation. I am proud to present our annual report on research for 2012. -Every year, Cincinnati Children's treats hundred of children who suffer from the rare diseases of childhood. Our world renowned research teams are learning what causes these illnesses and how best to prevent and treat them. Our works starts at the very beginning of life when babies are born much too early, their under-developed lungs lack surfactant, a substance that allows lungs to smoothly expand and contract. Years ago, our scientists helped developed a synthetic form of surfactant that has saved many lives. Now our researchers seek to improve the formula by adding surfactant D to the compound. Doctors here also were conducting trials of VX770, a drug that could allow some patients with cystic fibrosis to live decades into adulthood by restoring their lungs' ability to clear mucus and harmful bacteria. Now our scientists are studying whether combining VX770 with other drugs can help even more patients. On another front, scientists at Cincinnati Children's have developed a gene therapy that may become a breakthrough treatment for Sickle Cell Disease, the first clinical trial of this new treatment will begin this year. For children who received organ transplants, our doctors have developed several ways to improve long term survival even so the supply of donated organs remains far short of demand to help more children. Our surgeons predict that mechanical devices will play an ever greater role in transplants over the future. On the cancer front, our researchers have discovered a compound that regulates inflammation and appears to stop tumor growth. They also have found a way to rejuvenate aging bone marrow stem cells, a discovery that could improve cancer treatment while shedding light on the human aging process. Breakthroughs like these are just a sample of what happens every day at Cincinnati Children's. Every patient, every procedure brings new insights to our researchers and clinicians as they work side by side to solve the unsolvable and transform medical care for children worldwide.