Don't lie to your children and tell them their medicine is going to taste yummy if it's not. "Once your kids get to the age of reason -- usually 3 and older -- you can explain that the medicine is going to make them feel better," Dr. Tolcher says. "Appealing to kids' sense of reasoning can be a powerful tool." It works for Kristine Mancusi, of Wallington, New Jersey. "I tell my 6-year-old daughter and my 2-year-old son the truth -- that whatever prescription I am giving them will make their hurt go away," she says. "I'm lucky. They take it, and that's it." And don't refer to medicine as candy. "Never do that; you don't want them to seek it out and risk overdosing," Dr. Tolcher says.