Posts Tagged ‘ genes ’

Red-Hot Parenting Recap February 2013: Child-Haters, Genes, Parenting, and Barriers To Services

Thursday, February 28th, 2013

February 2013 was a busy month in the world of parenting – lots of things going on. Here’s a snapshot: 

CHILD-HATERS

The news that an adult male slapped a stranger’s toddler on a plane led to a conversation about how our culture may be breeding, at a minimum, a lack of respect for our youngsters – and at worst, provide a context in which child-hating is tolerated.

GENES

Speaking of conversations, we had many about if we should use what we are learning about genetics to support genetic engineering, including targeting childhood psychiatric disorders. Then came news that new research suggests some genes might predispose to a number of forms of mental illness – but it’s not at all clear that this will move us closer to genetic solutions.

PARENTING

We always include applications of current research to help guide us decide on good parenting strategies. One study suggest how important it is to let your toddler – and not you – be the “boss” when you are playing. And compelling research showed how the simple act of turning off violent shows and replacing them with educational content – without limiting the amount of TV watched – is beneficial for kids.

BARRIERS TO SERVICES

We took on some key barriers to getting kids mental health services and broke them down in understandable turns. Now we all wait to see if sequestration is going to provide the biggest barrier of all.

Time For Review via Shutterstock.com

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Are There Mental Illness Genes?

Thursday, February 28th, 2013

For decades, researchers have tried to identify (with, as an overall statement, little success) the genes that contribute to a number of forms of mental illness. The idea has been to find genes that are specific to disorders. But a study suggests that some genes may predispose to a wide range of disorders.

Consider this new study which involved over 61,000 subjects. Four regions of the genome were found to increase risk for each of the following disorders: ADHD, autism, bipolar disorder, major depressive disorder, and schizophrenia.

Decades of family and twin studies have suggested that the genetic boundaries between forms of mental illness may not be as clear as the diagnostic categories we use. So it may not be entirely surprising that we are seeing “general” genes that may predispose to a wide range of forms of mental illness – many of which have overlapping characteristics.

To be sure, some specificity may reside in DNA that distinguishes schizophrenia from, say, ADHD. But we are at the beginning stages of sorting through the newer idea that there may also be regions of the genome that may offer either general protection against, or risk for, mental illness in general.

The etiological puzzle continues to get more complex, and more intriguing, the more we look into it. The prospect for more research to uncover interesting findings is strong. But given all this complexity, the prospect that it will lead to immediate improvements in therapeutics seems far in the distance (but then again, no one knows for sure).

Molecular Biology Test via Shutterstock.com 

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Better Environments And Less Drugs For Kids With ADHD?

Sunday, January 29th, 2012

A provocative essay published in the New York Times suggests that Ritalin (and other stimulant drugs) is essentially ineffective for treating ADHD when one looks at kids’ behavior over time – and that what’s missing (and what’s needed) is a much stronger focus on the psychosocial environment and not pharmaceuticals. 

There are two parts to this argument that I agree with and wish to expand on.

First, even though ADHD is believed to be highly heritable (based primarily on twin studies), this does not mean that kids with ADHD will not respond to changes in their environment – or that genetic or biological treatment is the only form of effective treatment. In fact, much of the most salient research on kids’ behavior problems conducted over the last decade has shown that “risk genes” are in fact highly responsive to the environment. Some studies have shown that psychosocial interventions work especially well for kids who have a “risk gene” (or more technically in these studies an allelic combination that confers the highest risk for a given disorder – such as two copies of the short arm of the serotonin transporter gene when examining depression). While this work has not been applied yet to ADHD it is becoming clear that genes and environment come together in specific and sometimes counterintuitive ways – and that kids who are at high risk genetically may also be highly likely to benefit from positive changes in their environment.

Second, perhaps the most important contribution of the essay is to point out that drug treatments for kids need to be evaluated over time and sometimes over years in order to understand how effective they really are. Through this lens I think it would be irresponsible to say that drug treatments alone produce the most beneficial developmental outcomes for kids with ADHD – modifying and structuring their environment is critically important.

While I appreciate the strong sentiment expressed in the essay, I do take a more balanced view in that I understand that some kids respond well to drugs such as Ritalin. But I see drug treatments for kids as a last step in a complex process that should start with, and focus heavily on, discovering what changes can be made in the psychosocial environment. This process ideally involves a partnership between clinicians, parents, and teachers. Once that is in place and executed over time, rational decisions can be made about the added value of considering drug treatment. In some cases introducing a drug into the mix may in fact make all the environmental changes that much more effective.

The bottom line is that it’s become necessary to champion the environment in an era of science and treatment that is infatuated with DNA and biology. Virtually all behavioral traits and disorders not only reflect genetic and environmental influences – much of the cutting edge research shows how the expression of genes are often dependent on the quality of the environment. And in the case of ADHD, it’s very important to reorient thinking about treatment to be sure that the essential and powerful role of environmental change is not forgotten.

Image of molecular ball and stick model via Shutterstock.com

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