Chemical that Readies Womb for Embryo Implantation Identified

A new study from British researchers have identified a chemical, secreted by healthy embryos, that signals the womb to make itself receptive to implantation and pregnancy.  The findings have far-reaching implications for women who are struggling to achieve and sustain a pregnancy.  More from the researchers at Warwick Medical School:

Before implantation, human embryos are genetically very diverse. Some embryos will contain no normal cells at all while others contain a mixture of normal and abnormal cells. Hence, no two human embryos are the same at this early stage of development.

The article, published today in Scientific Reports, shows that high quality human embryos secrete a chemical, trypsin, which renders the lining of the womb supportive of implantation. This chemical signal is deregulated in low quality embryos and causes an alarm response in the womb, which leads to either rescue or elimination of the embryo.

Professor Jan Brosens explained, “This is important, because if the lining of the womb is not well prepared for pregnancy you may find that abnormal embryos will implant or high quality embryos will not be supported. Both scenarios can lead to pregnancy loss or even late pregnancy complications, such as foetal growth restriction or preterm birth.”

“Speaking in terms of an entrance exam; a poorly prepared womb will either make the test too rigorous or too lax – decreasing the chances of a successful pregnancy.”

Approximately 15% of clinically recognised pregnancies miscarry, attributed to the invasive nature of the human embryo and prevalence of chromosomal errors.

Professor Siobhan Quenby said, “This work adds to a growing body of evidence that assessment and optimisation of the lining of the womb may be the only effective way in preventing infertility and pregnancy complications.”

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