Anti-Nausea Drug Safe for Pregnancy, Study Finds

A Danish study has found that Zofran, an anti-nausea drug that’s given to pregnant women who suffer from severe morning sickness, does not harm a growing fetus.  More from USA Today:

One in 10 pregnant women has nausea and vomiting bad enough to need medicine but many forgo it out of fear of side effects. No drugs are currently approved for morning sickness in the United States although doctors are free to prescribe whatever they believe is best.

Zofran, sold by GlaxoSmithKline and in generic form for treating nausea from cancer treatments and other causes, has been the top choice. Yet women and doctors have been leery of it because a small study previously suggested it might raise the risk of a birth defect — cleft palate.

The new study of more than 600,000 pregnancies in Denmark found no evidence of major birth-related problems, so women should not be afraid to use Zofran if they need it, said Dr. Iffath Hoskins, a high-risk pregnancy specialist at NYU Langone Medical Center and a spokeswoman for the American College of Obstetricians and Gynecologists.

“It’s effective and it’s safe,” she said. “Nobody is giving you a gold star for suffering through this.”

Poor nutrition because of excessive vomiting can harm the woman and the fetus, she said.

Image: Woman with morning sickness, via Shutterstock

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  1. by Kate Lanfis

    On March 1, 2013 at 10:05 pm

    My child’s gastrologist says Zofran is being researched as a link to causing severe food allergies. I took Zofran many months of pregnancy and can’t help wondering its role, if any, in my son’s poor health.

  2. by Daihana

    On March 3, 2013 at 9:52 am

    I was on Zofran for about a month back in Dec. & thank for it as i thought i would die. Wished would gotten on them sooner as i had lost 24 pds within a month & a half & would vomitte up to 13x’s per day. Two wks in the hospital was overwhelming just as well.

  3. by Sheila

    On March 3, 2013 at 10:22 am

    Zofran is great for the nausea but if you are taking it be warned it can cause bad constipation, drink 2 litres of water or non fizzy juice and eat a lot of fibre. I was on this during my pregnancy and ended up in a spiral of constipation making me queasy taking Zofran and getting worse especially when my doctor suggested upping the dose. I don’t want to put anyone off but just want to say if you do use it take precautions against constipation :) water water water and more water.

  4. by Heather

    On March 3, 2013 at 10:35 am

    I took zofran just about the entire time because I would get soo sick if I didn’t take it. I didn’t have the constipation issue as I drank lots of fluids anyway. And the baby is in great health. She is now 2 1/2 and no allergies or really hasn’t ever been sick. Before starting it, I was puking up everything. Ice, water, crackers, milk, dry heaving. Everything. So Zofran was great for me.

  5. by Megan

    On April 12, 2013 at 9:49 am

    I took Zofran in the first half of my pregnancy and it was amazing! Before I was prescribed it, I would get sick 10+ times a day and I couldn’t keep ANYTHING down! I lost almost 10 pounds and looked terrible. The rest of my pregnancy has been great and my little girl is healthy and active as can be!